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Dr.Satish Srinivas. K

Dr.Satish Srinivas. K

Professor & Head

Area of Specialization
Radiation Oncology

Post MD experience
21 years

Publications: 

Publications – 40 (total)

Citations       243

h-index 8

i10-index 7

Additional Training – 

1) Observorship in Stereotactic RT at Apollo Hospitals Chennai – 2007.

2)  Training in IGRT, Rapid Arc and Gated Radiotherapy in Madam Curie Cancer Center 

     Poland in 2013.

4) Training in Cyberknife and Prostate Seed Implant Brachytherapy at CBCC Cancer 

    Center Bakersfield, California in September 2014.

CLINICAL EXPERIENCE

  • Planned and treated more than 7,000 patients successfully with various RT techniques over the last 21 years in various RCC’s of South India and reputed radiation centres in Chennai.
  • Founder Head of the Dept of Radiotherapy (from Aug 2005 to June 2008) at SVIMS.
  • Currently Founder Head and Professor, Dept of Radiation Oncology at SRMC. Helped to establish a state-of-the-art RT centre at SRMC which started clinical treatment from Jan 2017.The Dept is equipped with VERSA HD linac fitted with the 160 leaf MLC Agility and USG image guidance system Clarity which is the first of its kind in South India. 
  • Life member of  AROI (Association of Radiation Oncologists of India -National organization and TN and PY state chapter)
  • Life member of ISO (Indian Society of Oncology)
  • Life member of NMO (National Medical Officer’s Organization)

RESEARCH EXPERIENCE

Research Focus – Radio Genomics and Radiation resistance, Radiation biomarkers as a                                prognostic tool, Targeted therapy in Head and Neck cancer

  1. Publications

                 TOTAL –  40  

                  H index -     8

                  I 10 index -     7

                 Citations -    243

    LIST OF PUBLICATIONS -

  1. Insights on the radiation-induced adaptive response at the cellular level and its implications in cancer therapy. Thathamangalam Ananthanarayanan A, Raavi V, Srinivas Kondaveeti S, Ramachandran I, Perumal V. Cytogenetic and Genome Research. 2023 Oct. DOI: 10.1159/000534500. PMID: 37906989. (PUBMED INDEXED – IMPACT FACTOR -1.94)
  2. Adenoid cystic carcinoma of the lacrimal gland in a child. Srinivas S, Sneha LM, Barathi G, Lakshmi JS, Srinivas S, Mukherjee B, Koka K. Pediatric Hematology Oncology Journal. 2023 Sep 1;8(3):188-90. (SCOPUS INDEXED. IMPACT FACTOR -1.7)
  3. Polymer blended Acalypha indica bioactive for potential wound dressing applications through solvent casting – An Experimental Interrogation. Biomass Conversion and Biorefinery. Jayasutha Jayram, Satish S. Kondaveeti, Christian Gnanaraj Johnson, and Mangathayaru Kalachaveedu. July 2023. Page 1-13. (SCOPUS INDEXED . IMPACT FACTOR 4.0).
  4. Development and Evaluation of the Psychometric Properties of the Tamil Version of Eating Assessment Tool − 10 (EAT10): Preliminary Findings from Persons with Head and Neck Cancer Selvaraj, J.L.; Venkatesh, L.; Varadharajan, V.; Chandrasekar, K.; Srinivas, S.; John, C.. Indian J. Otolaryngol. Head Neck Surg. 2023, 75, 632–640, doi:10.1007/s12070-022-03376-8. (PUBMED INDEXED. IMPACT FACTOR 0.6).
  5. Establishment of ex vivo calibration curve for X-ray induced “dicentric + ring” and micronuclei in human peripheral lymphocytes for biodosimetry during radiological emergencies, and validation with dose blinded samples. J. Vijayalakshmi  , Rajesh Kumar Chaurasia , K. Satish Srinivas . Heliyon. June 2023. 9. (6). (PUBMED INDEXED. IMPACT FACTOR 4.0) 
  6. Candidate gene expression in regional population and its relevance for radiation triage. K. Vijayalakshmi  , Solomon F.D. Paul  , N.N. Bhat  , B.K. Sapra  Kannan N, Koshy T, Raavi V, Bhaskar E, Moorthy S, Pulivadula Mohanarangam VS, Srinivas Kondaveeti S, Visweswaran S, Perumal V Cytogenet Genome Res. 2023 May. (PUBMED INDEXED Impact factor -1.94). 
  7. Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence. Murali R, Balasubramaniam V, Srinivas S, Sundaram S, Venkatraman G, Warrier S, Dharmarajan A Metabolites. 2023; 13(4):560. (Imp factor -5.58) 
  8. The targeted next-generation sequence revealed SMAD4, AKT1, and TP53 mutations from circulating cell-free DNA of breast cancer and its effect on protein structure - A computational approach. Ambritha Balasundaram , Udhaya Kumar S , Thirumal Kumar D , Aditi Anil Dedge , Gnanasambandan R , Satish Srinivas K , Siva R , George Priya Doss C J Biomol Struct Dyn. 2023 Apr 3:1-14.  (Impact factor – 5.23). 
  9. An integrated investigation of structural and pathway alteration caused by PIK3CA and TP53 mutations identified in cfDNA of metastatic breast cancer. Hephzibah Cathryn R Udhaya Kumar S.| Gnanasambandan R.P. Jeyaprakash Naayanan| P. Sathiyarajeswaren M. S. Shree Devi  Satish Srinivas K. | George Priya Doss C. J Cell Biochem. 2022;1–17. (Impact Factor – 4.481). 
  10. Profile of paediatric optic gliomas experience from a tertiary care centre in South India. Shree Hasitha Koneru, Bipasha Mukherjee, Kirthi Koka, Dhaarani Jayaraman, Julius Scott, Sneha Latha, Preeta Nair, Satish Srinivas. Pediatric Blood & Cancer. Volume 69. Pages

S298-S299. 

  1. Chromosome length ratio as a biomarker of DNA damage in cells exposed to high dose ionizing radiation C. Meenakshi a,, P. Venkatachalam ,  K. Satish Srinivas , S. Chandrasekaran , , B. Venkatraman . Mutation Research - Genetic Toxicology and Environmental Mutagenesis 879–880 (2022) (Impact Factor – 3.18). 
  2. Impact of COVID-19 Pandemic on Patterns of Care and Outcome of Head and Neck Cancer: Real-World Experience From a Tertiary Care Cancer Center in India. Venkatasai J, John C, Kondavetti SS, Appasamy M, Parasuraman L, Ambalathandi R,Masilamani .JCO Glob Oncol. 2022  (Impact Factor - 4.33)    
  3. Evaluation of the Psychometric Properties of the Tamil Version of Eating Assessment Tool − 10 (EAT-10): Preliminary Findings from Persons with Head and Neck Cancer. Jasmine Lydia Selvaraj, Lakshmi Venkatesh, Vasudharany Varadharajan & Kavyashree Chandrasekar Satish Srinivas & Christopher John. Indian J Otolaryngol Head Neck Surg (2022). (Impact factor -0.56). 
  4. Challenges and Prospects of Development of Herbal Biomaterial Based Ethical Wound Care Products—A Scoping Review. Jayasutha Jayram, , Satish S. Kondaveeti, Christian Gnanaraj Johnson, Preethi J. Sampath, and Mangathayaru Kalachaveedu. The International Journal of Lower Extremity Wounds. (accepted in Oct 27 -2021) -  (Impact factor -2.05). 
  5. Prognostic significance of metabolic tumour volume and maximum standard uptake value of fluor-18-fluorodeoxyglucose positron emission tomography with computed tomography in nasopharyngeal carcinoma. John C, Venkatasai J, Kondaveeti SS, Murali A, Periakaruppan G, E V, Meenakshisundaram M, Ambalathandi RC, Masilamani H. Contemp Oncol (Pozn). 2021;25(3):153-159. (Pub Med indexed). 
  6. Asymptomatic palatal mass: A case report. Divyambika CV, Srinivas KS, Subramanian SS, Elengkumaran S, Malathi N. Indian J Dent Res 2021;32:120-23. (Pub Med indexed). 
  7. Concurrent Taxol-Based Doublet Chemotherapy as an Alternative for Intracavitary Brachytherapy Boost in Locally Advanced Carcinoma Cervix- Retrospective Analysis From a Tertiary Care Center. John C, Venkitaraman B, Masilamani H, Kondaveeti SS. Cureus. 2021 Jul 11;13(7).  (PubMed Indexed). 
  8. Herbal supplement usage among cancer patients: A questionnaire-based survey. Kanimozhi T, Hindu K, Maheshvari Y, Khushnidha YG, , Srinivas KS, Manickavasagam M, Mangathayaru K. J Cancer Res Ther. 2021 Jan-Mar;17(1). (Impact factor – 1.331). 
  9. Turmeric supplementation improves the quality of life and hematological parameters in breast cancer patients on paclitaxel chemotherapy: A case series. Kalluru H,  Kondaveeti SS, Telapolu S, Kalachaveedu M.  Complement Ther Clin Pract. Volume 41, November 2020. (Impact factor – 1.701).. 
  10. Nimotuzumab with intensity-modulated radiation therapy in unresectable and platinum-ineligible, locally advanced head-and-neck cancer. Srinivas KS, Sundaram R, Divyambika CV, Chaudhari S. South Asian J Cancer. 2020 Jan-Mar;9(1):43-46. (Pub Med Indexed).  
  11. The Prognostic Role of Maximum Standardized Uptake Value of 18 F-FlouroDeoxy Glucose Positron Emission Tomography-Computed Tomography in Head and Neck Cancer Patients Undergoing Chemoradiotherapy. Srinivas KS, Arunan M, Venkatachalapathy E, John C, Manickavasagam M, Divyambika CV. J Int Soc Prev Community Dent. 2019 Mar-Apr;9(2):159-165. (Pub Med indexed). 
  12. Therapeutic Benefit of Placentrex in the Management of Acute Chemo Radiation Induced Mucositis in Oral Cancer Patients. Kondaveeti SS, C V D, John C, M M, S R Asian Pac J Cancer Prev. 2018 Nov 29;19(11) (Pub Med indexed). 
  13. Comparison Of X-Ray In Vitro Dose Response Of Chromosomal Aberration And Micronuclei Using Manual & Automated Scoring.  Monisha, Anoopa; Ambiga, Bhaskar; Ashvitha B.; Janani R.; Femeela, Ireene; Vharshini M.; Vijayalakshmi J.; Srinivas, Satish; Sukumar, Prabakar; T. M., Hemavathi; S. F. D., Paul .  Nitte University Journal of Health Science . 2018 Special Issue, p64-64. 1p.
  14. Validated RP-HPLC Method for Quantification of Paclitaxel in Human Plasma – Eliminates Negative Influence of Cremophor El. Hindu Kalluru, Vinodhini C., Satish Srinivas K., Surulivel Rajan M. Chitra K., Mangathayaru K.  Int J Cur Res Rev | Vol 10 • Issue 13 • July 2018. (Indexed in J gate, EBSCO and Google Scholar). 
  15. Paediatric Peripheral Primitive Neuroectodermal Tumour - A Clinico-Pathological Study from Southern India. Rajendran R, Joseph LD, Johnson T, Sneha LM, Scott JX, Srinivasan S. J Clin Diagn Res. 2017 Sep;11(9) (Pub Med indexed). 
  16. Molecular Markers For Capecitabine Therapy: A Review. S. Ramalakshmi *, S. Kavimani, Satish Srineevas, V. Vetriselvi and LVKS Bhaskar. IJPSR (2016), Vol. 7, Issue 11.4315-4326. (Indexed in Google Scholar). 
  17. A Pharmacogenetic Study Of Capecitabin.  Oxaliplatin Therapy In Colorectal Cancer Patients Among South Indian Population. S. Ramalakshmi*, S. Kavimani, Satish Srineevas, V. Vettriselvi and LVK S Bhaskar. European Journal Of Pharmaceutical And Medical Researche- 2016, 3 (9), 520-528. (Indexed in Google scholar). 
  18. Tumor targeting using poly amidoamine dendrimer-  cisplatin  nanoparticles  functionalized with diglycolamic acid  and  herceptin. Kesavan A, Ilaiyaraja P, Sofi Beaula W, Veena Kumari V, Sugin Lal J, Anjana G, Srinivas S, Ramesh A, Rayala SK, Ponraju D, Venkatraman G. Eur J Pharm Biopharm. 2015 Oct;96:255-63. (Impact Factor -5.5) . 
  19. Impact of Patient Counselling on Medication Adherence, Beliefs and Satisfaction about Oral Chemotherapies in Patients with Metastatic Cancer at a Super Specialty Hospital. Anita Ramesh, M.G. Rajanandh, S. Thanmayee, G. SalaghaMerin, S. Suresh and K. Satish Srinivas.  International Journal of Cancer Research 2015, 11 (3): 128-135, 2015. (indexed in SCIMAGO and SCOPUS) . 
  20. Double pathology – Malignant epithelial ovarian tumor and germ cell tumor      (choriocarcinoma)-a rare co-existence. Shanmugasundaram G, Sundaramoorthy E, Sudalaiandi S, Kondaveeti SS, Johnson T, Swaminathan R, Ramesh A. World J Oncol. 2015 Aug;6(4):421-425. (Impact factor -0.98). 
  21. Therapeutic Benefit of Concurrent Radiation With Single Agent Nimotuzumab in Locally Advanced and Recurrent HNSCC: A Retrospective Analysis- Kondaveeti, S.S.. R. Sundaram International Journal of Radiation Oncology, Biology, Physics, Volume 90, 2014 Issue 1, S561. (Impact Factor -8.013). 
  22. Complete clinical response to neoadjuvant chemoradiation in rectal cancers: can surgery be avoided? Ayloor Seshadri R, Kondaveeti SS, Jayanand SB, John A, Rajendranath R, Arumugam V, Raj Ellusamy H, Sagar TG. Hepatogastroenterology. 2013 May;60(123):410-4 (Impact Factor – 0.9).  
  23. Non-hodgkin's lymphoma involving base of tongue. Divyambika C V, Srinivas K Satish, Shanmugam S.JIAOMR 23:(4)2011 | Volume:  23 | Issue Number:  4 | Page: 627-629 (Second Author) (Indexed with SCOPUS.). 
  24. Hypertrophic Osteoarthropathy in nasopharyngeal carcinoma.  A  rare  differential diagnosis . Satish K Srinivas, Arunkumar, Vasanthan A, Divyaambica CV, Sathasiva Subramanium S, Majhi U, Krishnakumar R, Aravind Krishnamurthy.. Int J Head Neck Surg 2010; 1(3): 171-173 (Indexed with Proquest  and EBSCO). 
  25. A Fatal Case Of Mesenchymal Chondrosarcoma Of The Mandible.  Krishnamurthy A, Vaidhyanathan A, Srinivas S, Majhi U. J Cancer Res Ther. 2011 Apr-Jun;7(2):192-4 (Impact factor – 1.331). 
  26. Cancrum Oris Associated With Acute Myeloid Leukemia : A Forgotten Disease..    Arvind Krishnamurthy, Anita Vaidhyanathan,, Satish Srinivas, Shirley Sundersingh,, Krishnarathinam. Int J Head Neck Surg 2010; 1(3): 167-169.. (Indexed With Proquest  And EBSCO).
  27. Esophageal metastasis from thyroid carcinoma. Aravind Krishnamurthy, Siddappa K T, Shirley Sundersingh, Satish Srinivas, Krishna Kumar.  Int J Head Neck Surg 2010; 1(2): 129-131. (indexed with  Proquest  and   EBSCO). 
  28. Leiomyosarcoma Of The Vulva . Patnayak R, Manjulatha B, Srinivas S, Reddy MK, , Jena A Indian J Pathol Microbiol. 2008 Jul-Sep;51(3):448-9. (Impact factor -0.773) . 
  29. Role of template guided interstitial implants in breast conservation therapy. Srinivas SK, Reddy KS, Vivekanandam S, Parthasarathy V. J Cancer Res Ther. 2005 Apr-Jun;1(2):79-83. (Impact Factor -1.331).
  1. Research Project Details – 
  1. PhD Guide – 1 Project – Ongoing
  2. Co –Guide and RAC member for 11 PhD Projects – Degree Awarded -3. Ongoing - 8 
  3. University Gate Projects – 2. (Ongoing)  (Co Pi)
  4. Summer Research Project – 1 (Ongoing) (Co Pi)
  5. Pharma Drug Trials Conducted – 3 (Co-Pi) 
  6. BRNS Research Grant – 2 – (Co Pi) – 1 Completed. 1 Ongoing
  7. AERB Research Grant – 1 – (Co Pi)  - Ongoing to be completed shortly
  8. SERB Research Grant – 1 (Co – Pi) . Ongoing.
  9. ICMR research Grant  - 2 (Co –P1) – Completed 1, Ongoing 1

III) List of funded research projects -     7.

1) SPARC – A tiered biodosimetry approach for the management of large scale radiological and nuclear emergencies. SPARC /2019-2020P1776/SL Dt:28-07-23. Amount – Es 64 lakhs

2) SERB (DST) - " Development of Elastin based protein nanogels targeted delivery system of combo drugs Enzalutamide/Decursin for Castration Resistance Prostate Cancer (CRPC) Therapy" Recommended in Dec 21. Amount – Rs 54 lakhs.

3) AERB - Establishment and capacity building for rapid radiation triage and dose estimation using biodosimetry approach  DAE, BRNS - Identification of novel molecular marker involved in radio resistance in prostate cancer. GRANT NO - 35/14/19/2014-BRNS/0361. Completed – 2018 . Rs 27 lakhs.

4) DAE, BRNS - Identification of novel molecular marker involved in radio resistance in head and neck cancer. Sanctioned in 2020.  To commence shortly.

5) ICMR – Development of novel silymarine gel for therapeutic application in Oral Sub Mucous fibrosis. Sanctioned 2023. Rs 33.60 lakhs 

6) GATE PROJECT –Characterization optimization and clinical efficacy assessment of Acalypha Indica based biofabricate in radiation dermatitis wounds – A RCT. (Co PI)

7)  GATE PROJECT – Antioxidants supplementation and glutathione evaluation by in vitro HPLC. Assay in Head and Neck squamous cell cancer cell lines. (Co – PI)

PATENTS IN PROCESS –

1) Development of Elastin based protein nanogels targeted delivery system of combo drugs. Enzalutamide/Decursin for Castration Resistance Prostate Cancer (CRPC) Therapy.

2) Acalypha Indica based biofabricate in radiation dermatitis wounds.

INVITED LECTURES AND CONFERENCE FACULTY –                                 

  1. Delivered a guest lecture at SRMC, Chennai  on Current Trends In Oral Cancer Management . - in Aug 2010.  
  2. Delivered a lecture on current role of Radiotherapy in Cancer Prostate management at the Uro Genital Cancer symposium held at Adyar Cancer Institute in DEC 2010. 
  3. Delivered a lecture  on current role of radiotherapy in cancer lung management at  the  lung cancer  CME held at Adyar Cancer Institute in Aug 2011.
  4. Delivered a guest lecture on a radiation oncologists perspective of oral cancer management held at Adyar Cancer Institute in Sep 2011.
  5. Delivered an Oration on newer frontiers in oral cancer treatment in the 25th International Conference Of Dental  Research  held  at  Chennai  in Oct 2012.
  6. Participated in a debate on the role of Pre op RT in rectal cancers in the International Rectal Cancer Update held at Adyar Cancer Institute  in Feb 2012.
  7. Delivered a guest lecture on New Frontiers In Radiotherapy of Oral Malignancies in the 25th International ISDR Conference held at Chennai in October 2012.
  8. Delivered a guest lecture on Guidelines on  Management Of STS (best of ESMO) at the  2nd conference on Clinical Practice Guidelines In Oncology and highlights from ESMO held at Chennai in Dec 2012.
  9. Delivered a guest lecture on Myths Of Cancer at Nursing College at SRMC in FEB 2013.
  10. Delivered a guest lecture on new trends in Cancer Cervix Management at city Onco Gynec meet in June 2013.
  11. Delivered a guest lecture on cancer awareness at Veltech University in Feb 2014.
  12. Delivered a guest lecture in pathology symposium on molecular oncology of breast cancers in April 2014. 
  13. Panelist in AROI meet on Head and Neck cancers in Vellore in June 2014
  14. Delivered a guest lecture on role of nursing, in radiotherapy in CNE on Oncology Nursing, at SRU in July 2014.
  15. Delivered a guest lecture on role of Modern day RT for Pediatric Malignancies at 1st Gynceco Paediatric malignancies conference at Kanyakumari in October 2014.
  16. Delivered a guest lecture at CPG meet in Dec 2014 at Chennai
  17. Panelist  at CME on endometrial malignancies at SIMS Chennai on 8-03-15.
  18. Guest lecture on expert exchange programme at Indore in July 2015.
  19. Participated in debate on laryngeal cancer HANOCON  Aug 2015
  20. Invited expert and fcaulty at REAL WORLD CASES with BIOMAB at international summit on Nimutuzumab in practise at Colombo 2014 and Bentota Sep  2015
  21. Role of RT in Wilm’s tumor PG symposium on Wilms tumor Srmc Chennai SEP 2015
  22. Delivered a guest lecture on RT in breast cancer at GVN hospital in Trichy in Oct 2015. 
  23. Delivered a guest lecture on breast brachytherapy in CME on breast cancer at Thrissur in Feb 2016.
  24. Panelist on role of monoclonal antibodies in head and neck cancer at Asian Oncology Summit meet in Delhi in April 2016.
  25. Chairperson for CNS tumors in AROI state conference held at Chennai in Nov 2016.
  26. Panelist in head and neck cancer , at National AROI meet , Bubaneshwar in Nov 2016.
  27. Guest lecture on trends in oral cancer management in Annual Post Graduate Rapid Review programme by Dept of Oral Medicine And Radiology at SRMC on 19th Jan 2017.
  28. Chair person in session on Dynamic Radiosurgery in Elekta India Radiation Oncology & Neuro Summit meeting held at Delhi on 25-02-17.
  29. Invited speaker in Scope 17 conference on cause to cure of oral cancer held at Sathyabhama dental college in 4-05-17
  30. Invited speaker in CME on targeted therapies in head and neck cancer at RCC, Kanchipuram on 21-09-17.
  31. Participated as chief guest and delivered a guest lecture on molecular trends in Immuno – Oncology at CME conducted by SRM Dental College on 25th  Oct 2017.
  32.  Panelist at CPG meet at Chennai in Dec 2017
  33. Guest lecture on trends in oral cancer management in annual post graduate rapid review program conducted by Dept of Oral Medicine and Radiology at SRMC on 19th Jan 2018.
  34. Panelist at symposium on genomics in medicine.in SRIHER , Chennai on 31-1-18
  35. Guest lecture on cancer awareness at Patrician College Chennai in Feb 2018
  36. Guest lecture on head and neck cancer diagnostics in Onco Quest 2018 conference at Rajas Dental College Wadakangulam in Sep 2018
  37. Panelist at State AROI meeting in Oct 2018.
  38. Panelist at IASO meeting in Chennai in Dec 2018.
  39. Guest lecture on oral cancer management in annual post graduate rapid review program me conducted by Dept of Oral Medicine and Radiology at SRMC in Jan 2019.
  40. Invited speaker at CANREHAB meet in Chennai in May 2019
  41. Panelist at State AROI meet in Thekkady in Sep 2019
  42. Panelist at FHNO meet in Chennai in Oct 2019
  43. Panelist at IMMAX meet in Chennai in Oct 2019
  44. Panelist in AROI webinar. CMC Vellore – Oct 2020
  45. Guest lecture on reproductive implications of RT at E CME by TAPISAR on 31-01-2021
  46. Guest lecture on update on oral cancer management in Post Graduate Rapid Review Program conducted by Dept of Oral Medicine and Radiology at SRMC in April 2021.
  47. Guest lecture on update on oral cancer management in Post Graduate Rapid Review Program conducted by Dept of Oral Medicine and Radiology at SRMC in April 2022
  48. Panelist at AROI meet held in Chennai in Oct 2022
  49. Panelist in IMMAX meet held in Chennai Oct 2022
  50. Panelist in ISMPO international conference in Chennai in Oct 22.
  51. Guest lecture in CDE program at Saveetha Dental College on Critical Thinkingin Jan 23.
  52. Panelist at ICNC 23 held at Chennai in Feb 23. 
  53. Guest Lecture at SRS and SRT conclave at American Cancer Center Ludhiana in Apr 23.
  54. Panelist in National conference on cancer nutrition. Chennai – July 23
  55. Panelist in AROI state conference Yercaud – Oct 2023.
  56. Panelist in CME on colorectal cancers . Chennai – Oct 23
  57. Panelist in ICC. Mumbai – Nov 23
  58. Panelist in IMMAX – Dec 23

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